MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma
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چکیده
منابع مشابه
Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
Overexpression of HMGA2 is common in uterine leiomyomas (ULM). The expression of HMGA2 in its malignant counterpart - uterine leiomyosarcomas (ULMS) remains undetermined. Recently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. To test whether HMGA2 and ...
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Leiomyosarcoma of the uterus is a malignant tumor arising from the smooth muscle of the uterus. It is a rare tumor with an incidence as low as 2%-5% of all uterine malignancies. Besides the conventional type, one of the important variants includes the epithelioid leiomyosarcoma which is by itself a rare subtype of leiomyosarcoma. The precise diagnosis of leiomyosarcoma is essential since it has...
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Uterine leiomyoma (UL), the most common benign tumour found in females, is associated with many recurrent genetic aberrations, such as translocations, interstitial deletions and specific germline mutations. Among these, mutations affecting exon 2 of the mediator complex subunit 12 (MED12) gene are commonly detected in the majority of ULs. Mutational analysis of the MED12 gene, performed on 36 U...
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Uterine leiomyoma is the most common benign tumor of genital tract. The etiology of myomas is unknown. Leiomyoma shows a broad spectrum of radiographic appearances depending on the number, size, and location of the tumor. The diagnostic method for uterine leiomyomas is based primarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginal sonography, sonohyste...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2014
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2013.243